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Translational Science - Medical Director (Neuroscience)

  • Permanent
  • ¥18000000 - ¥26000000 per annum
  • Japan, Japan
  • R&D

Top Global Pharmaceutical Company

OBJECTIVES:

    • To provide a key fulcrum of bidirectional translational research in Neuroscience
    • To facilitate a seamless transition of assets through the Company's Neuroscience (Neurology / Psychiatry) R&D portfolio, through deep engagement in discovery and seamless transition between discovery/ preclinical into early clinical research
    • To lead Translational Strategy Teams consisting of other Research and Clinical scientists to develop a Translational Research Plan, including design and oversight of preclinical and translational studies that will best inform clinical development
    • To lead matrixed platform functions in development of biomarkers and execution of Experimental Medicine studies to establish human models that will accelerate quantitative, disciplined Go/NoGo decisions earlier in development, based on biomarker-driven Early Proof-of-Concept studies
    • To develop and drive the Translational Research Plan as part of the overall Asset Strategy in the Global Project Team
    • This role embraces the principles of a translational/exploratory mindset, with a focus on operational excellence, and deep scientific rigor

ACCOUNTABILITIES:

    • Acts as a key interface between the Neuroscience Drug Discovery Unit scientists and Therapeutic Area Unit clinicians to ensure portfolio prioritization and seamless transition of programs between research and clinical development
    • Translational Medicine lead on the Global Project Team, leading development of the Translational Medicine strategy as part of the overall Asset Strategy
    • Drive projects to rigorous assessments of therapeutic success or failure by testing clear scientific hypotheses as early, leanly, directly, and quickly as possible in the preclinical, translational, and experimental medicine stages of development
    • Engages early (at lead optimization stage) with Neuroscience Drug Discovery Unit to assist in research portfolio prioritization, based in part on translation strategy
    • Provides Translational Medicine expertise and recommendations to Drug Discovery Unit on Go/No-Go decisions at candidate decision gates
    • Leads the Translational Strategy Team of the Global Project Team to support fluid/tissue biomarker, imaging, neurocircuitry biomarker (electrophysiology), and/or pharmacogenomic strategies and implementation
    • Creates the Translational Research Plan, integrating input from other functions as needed, including Basic Research, Translational Biomarker Research, Imaging, Neurocircuitry Biomarkers, Quantitative Clinical Pharmacology, Clinical Operations, and Clinical Science
    • Engages the Neuroscience Therapeutic Area Unit clinicians during TRP creation to ensure Translational Medicine studies support decision-making for late phase development.
    • Designs and implements clinical protocols for Experimental Medicine studies to test novel biomarkers and study designs in order to support earlier decision-making in development
    • Contributes to authorship, review and approval of other key documents, including investigator brochures and INDs/CTAs as needed as well as co-authored publications in scientific journals
    • Ensures agile, timely management of issues arising from ongoing studies, including serving as the study physician for adverse event reporting
    • Works closely with Clinical Operations, Procurement, and Legal functions to support clinical study implementation of Experimental Medicine studies
    • Provides Translational Medicine expertise for external opportunities, including participation in due diligence teams

EDUCATION AND KNOWLEDGE/SKILLS:

Education, Experience

    • MD preferred
    • Formal clinical training, including fellowship training with NS specialization, preferably Neurology in the areas of Movement Disorders or Neuromuscular Disease
    • Clinical development or translational/experimental medicine expertise preferred
    • Record of scientific publication
    • Minimum 3 years biopharmaceutical or CRO health-related consulting company or academic industry early clinical development experience

EDUCATION, LICENSES, CERTIFICATIONS:

    • Medical degree required
    • MD-PhD preferred
    • Board certification preferred

Allowances: Commutation, Housing, Overtime Work etc.

Salary Increase: Annually

Bonus Payment: Twice a year

Working Hours: 9:00-17:45

Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)

Paid Leaves: Annual Paid Leave, Special Paid Leave, Refresh Leave, Maternity Leave, Childcare Leave, Family Nursing Leave, Philanthropy Leave.

Flexible Work Styles: Flextime, Telework

To find out more about Real Staffing, please visit www.apac.realstaffing.com

Real Staffingについてもっと詳しく知りたい方はこちらへ→ www.apac.realstaffing.com/ja